Dose dependant decrease in cell multiplication was observed in the in vitro study. 20mg/ml concentration of 777 Oil was very effective in retarding the cell division to 90% level.
777 Oil at 50 mg/ml and above produced necrosis in the cell line.
The kinetics of cell division in the case of treated vs. untreated cells was 2:8. The nuclear spindle formation is arrested during the treatment of cells with 777 Oil. This phenomenon was studied by mitosis inhibition assay using onion root tip assay. 777 Oil arrest the cell division especially during the mid anaphase to metaphase stage.
Clinical and experimental studies on the efficacy of 777 Oil a herbal preparation - CCRAS
The efficacy of 777 Oil was confirmed on 300 cases taken up for trials in the out patient department of Central Research Institute, Siddha at Chennai, India between 1980 and 1986. The results were published in the Monograph by Central Council for Research in Ayurveda and Siddha (CCRAS), Ministry of Health and Family Welfare, Government of India, New Delhi in 1987.
The results together with the follow-up study indicated 777 Oil proved to be an ideal drug that provided marked relief from clinical symptoms, broke the cycle of recurrence, minimizes extent of complications and prevents complications completely. Long-term application did not invite or foresee any hazards, unlike steroidal formulations.
Papers presented in Domestic and International conferences by Dr. J.R.Krishnamoorthy
Dr. J.R. Krishnamoorthy and his associates have presented a number of research and clinical study papers in Domestic and International forums.
" Genesis of 777 Oil", presented at the Workshop on Psoriasis, organized by CCRAS, 1987
"Herbal treatment for Psoriasis" - A report on Clinical Research with special focus on Histopathological aspect - International Conference on Traditional Medicine Chennai 1986
"777 Oil, The Siddha herbal treatment for Psoriasis" - First World Congress on Oriental Medicines and Yoga, Bangkok 1988
Clinical trials done by Kilpauk Medical College Hospital , Chennai, India
30 patients were put to treatment with 777 Oil for a period of 12 weeks. In a majority of the cases, the clinical symptoms started receding within the period of study. 777 Oil was found to a great extent, an ideal drug for the treatment of Psoriasis. It was found to be clinically effective, Non-toxic, cosmetically acceptable and economic. The findings results of the above study done by Prof. Dr. J.M. Boopalraj, Dr. Frederick Manuel et al. were presented at the 23rd National Conference of IADV&L (Indian Association of Dermatologists, Venerologists and Leprologists) in 1995 at Chennai and later published in the March 1997 issue of "The Antiseptic" Medical Journal.
Paper presented at the 19th World Congress of Dermatology , Sydney , Australia
A paper titled " Treatment of psoriasis with Wrightia tinctoria leaf extract" was presented by Dr. Frederick Manuel at the above conference in June 1997. The paper highlighted that the extracts of the leaves of the plant are effective and inexpensive for the treatment of psoriasis and that most patients had long remissions on follow-up. The paper was presented on the basis on the basis of the trials done at the Kilpauk Medical College, Chennai.
Clinical trials at the Ram Manohar Lohia Hospital, New Delhi, India
Dr. H.K. Kar and Dr. Mrs.Vandana Jain an ICMR Member studied about 25 patients of either sex at the Hospital comparing the topical application of Calcipotriol and 777 Oil in the treatment of Psoriasis. Results were presented at the 25th National Conference of IADV&L at Guwahati, India in 1997. The study indicated that 777 Oil is a more acceptable and cost effective alternative for the treatment of Psoriasis. 777 Oil showed a higher percentage reduction of the mean PASI than Calcipotriol in the 12-week period.
Study done at King George Hospital , Visakhapatnam , Andhra Pradesh , India
Dr. P. Lakshmi, Professor and Head of Department of Dermatology together with her colleagues undertook a study on 30 patients showed that after the 12 week trial study 8 patients showed 100% improvement, 4 patients showed 75% improvement and 18 patients showed 50% improvement. Further studies of long term in nature are underway. The study concludes that Wrightia tinctoria does have a place in the treatment of psoriasis in maintaining remission and that it is safe, effective and inexpensive compared to other treatment modalities used in psoriasis patients.
Use experience reports of practising Dermatologists.
777 Oil and Psorolin Ointment have been drugs of choice for many practising Dermatologists in India and under their care, more and more patients are benefiting. Their observations have been encouraging. There are many more Dermatologists, General Physicians and practitioners of alternative medicines who share the observation. A few are presented below:
"An ideal drug for the treatment of Psoriasis should have all the following characteristics- Effectiveness, Relative non-toxicity, Cosmetic applicability, and Cheapness (economical) . In my experience I have found that 777 Oil satisfies all these parameters to a great extent"
" The more chronic the lesion the more striking is the improvement with the application of 777 Oil"
" 777 Oil can be considered as one of the drugs of choice for the treatment, control and overall management of Psoriasis"
" I have personally prescribed 777 Oil to some of my eligible patients and I found the results encouraging. Most of my patients got good remission"
" I would like to thank Dr. JR Krishnamoorthy for introducing 777 Oil on scientific lines in the treatment of Psoriasis and conclude that 777 Oil is really a breakthrough in the management of all types of Psoriasis"
"For the last few years I have been trying 777 Oil for my patients and I find the results are very effective in regard to several signs and symptoms affecting patients. Most of my patients had no remissions for a long period. None of my patients complained of any side effects"
" 777 Oil is an ideal drug for psoriasis and has no side effects"
" I have been prescribing 777 Oil and Psorolin Ointment to my Psoriasis patients and some cases of Seborrhic dermatitis with satisfactory results. Psorolin Ointment gives good results for Pityriasis Versicolor."
Effect of 777 Oil on co-stimulatory molecules in Psoriatic condition