|
|
|
 |
 |
Tolenorm
Oil & Ointment |
|
| |
| Studies and evaluation done on Tolenorm Oil/Ointment presented here are proprietary formulation of Dr. JRK’s Siddha Research and Pharmaceuticals Pvt Ltd |
Solutions
Vitiligo
Tolenorm oil and ointment composition-
Vitiligo photos |
| |
|
| |
|
| |
|
| |
Composition:
Each 5 ml contains
Extract of
| Vetpalai (Wrightia tinctoria ) |
:50 mg |
| Karboga arsi (Psoralea corylifolia) |
:50 mg |
| Avuri (Indigofera tinctoria ) |
:50 mg |
| Thippili ( Piper longum) |
:50mg |
| Thangai Ennai (Oleum Cocos nucifera) |
:Q.S |
TOLENORM Ointment is presented with the ingredients of Tolenorm Oil in Petroleum Jelly base. |
| |
Psorolea corylifolia
Oil extracted from the seeds of this plant helps to improve the color of skin, hair and nails. Extracts of Psoralea are extensively used in modern medicine for de pigmentary disorders of the skin.
Wrightia tinctoria
For the first time, extract of this is being successfully used for the management of Vitiligo. The therapeutic properties of extract is that it aids in the exfoliation of epidermis.
Indigofera tinctoria
These leaves are extensively used for skin disorders. These help in the restoration of natural color of the skin.
Piper longum
The fruits of Piper longum is said to be a good remedy for leucoderma.
Indication
TOLENORM Oil and TOLENORM Ointment are indicated in the management of all types of Vitiligo, hypo-pigmentary problems.
Contra-indication
There are no known contra-indications
Administration
Tolenorm Oil and Tolenorm Ointment are used for external application only.
TOLENORM Oil
| i. |
Apply over the depigmented surface once a day after bath. |
| ii. |
Expose the surface to sunlight (for about 5-10 minutes) after application. |
| iii. |
Apply regularly everyday until repigmentation is completed. |
TOLENORM Ointment
Application of Ointment is prescribed for small-localized lesions and for convenience during travel.
SUPPORTIVE THERAPY
CARATOL-E capsules, BEKAY capsules and S.I.V.A Herbal drops are recommended to be used along with Tolenorm.
Precautions:
Tolenorm Oil and Tolenorm Ointment contain ingredients with photosensitive activity and therefore must be applied with sufficient care. At the start of the treatment, a diluted mixture of Tolenorm Oil with Coconut oil is recommended. Treatment with the undiluted drug could continue thereafter.
Protect the normal areas of skin from sunlight by adequate clothing.
Exposure to sunlight should not be overdone and limited to 5 to 10 minutes even on cloudy days. When sunlight is not available.
Limit exposure of the area to sun for a shorter period of 2 to 3 minutes. Dilution of the oil with coconut oil and the ointment with liquid petroleum may also be taken up in the event of severe erythema. Normal usage may be resumed thereafter. Under any circumstances, excessive application of the drug is strictly to be avoided. In any odd situation physician should be contacted for management.
Diet and other recommendations.
Use of Synthetic garments, hair dyes, chemical cosmetics, tight fitting outfits, metal coated ornaments etc are not recommended.
Sour tasting food, artificially flavored eatables and beverages, processed food etc. are to be avoided. Food items prepared in a manner that could cause Gastro-intestinal disorders or susceptible to infection (amoebiasis etc) are to be avoided. Improved personal hygiene and that of the surroundings is recommended. Treatment of dental cavities, sinuses infections, acute or chronic, gastro-intestinal infections should be promptly treated.
Stress and tension are to be avoided and day long exposure to sunlight should be minimized. Adequate clothing to cover affected areas is recommended during outdoor work.
Presentation
TOLENORM Oil is presented in 50ml and 100ml containers
TOLENORM Ointment is presented in 50gms and 100gms containers. |
| |
|
Study done at Dr. JRK's Siddha Research clinical and research wing
Of the patients put on Tolenorm Oil and Tolenorm Ointment, in 30 % of the cases, pigmentation began before 8 weeks; in 50 % of the cases, extensive pigmentation was seen in 20 weeks; 50 % of the cases showed near total pigmentation in about 30 weeks and maintained the same or improved levels subsequently with no side effects.
Study done at Government Stanley Medical College, Chennai, India
A study titled "Efficacy of topical application of TOLENORM oil / ointment in the treatment of Vitiligo" was done under Dr. M. Jayaraman, Professor and Head of Department of Dermatology and Dr. G. Ravichandran, Department of Dermatology, Government Stanley Medical College, Chennai, India.
In the study, clinical trial with Tolenorm oil and Tolenorm ointment was conducted in 50 patients with different types of Vitiligo over a period of one year in the Hospital. 20 patients with focal Vitiligo, 15 with generalized type, 8 patients with segmental, 5 patients with Acral type and 2 with lip Vitiligo were treated with topical application of Tolenorm oil and Tolenorm ointment followed up for about one year for results.
Repigmentation began to appear in 6-8 weeks and near complete repigmentation was observed in segmental and focal Vitiligo in 9-10 months. Generalized Vitiligo showed 50% to 60% repigmentation. While Acral and lip Vitiligo showed insufficient response, only 2 patients showed irritant reaction. The results are being presented in the Annual conference of the IADV&L (Indian Association of Dermatologists, Venerologists and Leprologists) at Bangalore, India in January 2000.
Study at the Government Kilpauk Medical College Hospital , Chennai, India
A study is being done at the Government Kilpauk Medical College Hospital, Chennai, India titled "Effectiveness of topical application Tolenorm oil and Tolenorm ointment in the treatment of Vitiligo" by Prof. Dr. S. Gomathy, MD DD; Dr. Jayakumari Jeevan, MD DD and Dr. U.R. Dhanalaxmi, MD DD.
The efficacy of topical application of Tolenorm oil and Tolenorm ointment in the treatment of Vitiligo was studied in the Out Patient ward of Department of Dermatology in the Government Kilpauk Medical College Hospital, Chennai, India. Tolenorm oil and ointment are formulations made by Dr. JRK's Siddha Research and Pharmaceuticals Pvt. Ltd, Chennai, India.
The study has been done on 60 willing Vitiligo patients of different age groups and sex with different kinds of Vitiligo like focal, generalized, segmental, lip and tip and Acral type.
The study was done in two batches. The first batch of 37 patients have been through a study period of 15 months or 64 weeks and the second batch of 23 patients have been through a period of 12 weeks. The study was commenced in the month of May 98 for the 1st batch and in September 99 for the 2nd batch. The clinical study would continue for a further period and final observations and conclusions would be presented in detail. An interim report is now made on the basis of observations till date.
The clinical evaluation protocol included observations on the extent of repigmentation, side effects if any and recording of the same at regular intervals in a systematic form. The patients have been advised application of TOLENORM as prescribed and report progress regularly.
The findings may be summarized as below:
 |
Repigmentation started in all cases around 8 weeks. |
|
46 % of the cases showed nearly 50 % repigmentation at the end of 24th week. |
|
At the end of 52 weeks (one year), 56 % of the patients showed nearly 75 % repigmentation. |
|
At the end of 64 weeks (15 months) 57 % of the patients showed nearly 90 % repigmentation |
|
11% of patients showed total repigmentation at the end of 15months. |
Besides the above, many Dermatologists in India concur based on their clinical experience that Tolenorm oil and ointment form a safe and effective for the treatment of Vitiligo and hypo-pigmentary problems.
So Tolenorm Oil and Tolenorm Ointment are 100% safe, non-toxic and herbal preparations with no side effects. Dermatologists today therefore have reasons to put their patients on TOLENORM Oil and TOLENORM Ointment to obtain a long term, safe treatment methodology for Vitiligo.
|
| |
|
S.I.V.A
Drops |
|
| |
S.I.V.A BOOSTS PHAGOCYTE MEDIATED IMMUNITY
COMPOSITION
Each 30 ml contains
Extract of
| Sivanar vembu ( Indigofera aspalathoides) |
:125 mg |
| Valuluvai (Celastrus paniculatus ) |
:25 mg |
Akasagarudan kizhangu (Corallocarpus (Bryonia)
epigaeus) |
:125 mg |
| Karpooram (Cinnamomum camphora ) |
:125 mg |
| Thuthulai (Solanum trilobatum ) |
:10mg |
| Oil Base |
:Q.S |
Benefits of S.I.V.A
|
Enhance Phagocytosis almost 138% |
|
Prevents recurrence of infection |
|
Effective in management of auto immune disorders |
|
Scientifically proven* |
In vivo confirmation
|
Increased membrane stability and chemotacticity of the phagocytes while treatment with S.I.V.A is assumed. |
|
Membrane bound adhesion of S.I.V.A molecules in the peritoneal phagocytes both during in vitro and in vivo tests. |
Pharmacokinetics
* Onset of immune boosting activity occurs in 4-5 days of oral
Administration of S.I.V.A drops.
|
Extent of absorption is enhanced significantly when honey is co-administered. |
|
Enzyme based activation is presumed for the enhanced activity |
|
Carbon exclusion technique in animal model also proves the efficacy of S.I.V.A. |
|
S.I.V.A boosts the macrophage mediated immunity and also offers protection against diseases that occur due to defective macrophage mediated immunity. |
|
| |
Immunomodulatory properities of certain Siddha
drugs – PESIN and S.I.V.A
Boosting of phagocyte mediated immunity by S.I.V.A
Immuno protective effect of S.I.V.A in animals challenged with candida albicans
PUBLISED IN AYURVEDLINE PART-1 2005
S.I.V.A offer sufficient immune protection especially in the disease per se of experimental candidiasis. To find out any other effect that S.I.V.A has ,we performed antifungal assay to determine MIC (data not shown) .S.I.V.A at 200 mg/ml inhibits the growth of candidia.At sub MIC level,the death rate of Candida cells was near 90%. |
| |
Indication:
Auto immune disorders like psoriasis,Vitiligo,Rheumatoid arthritis and in immune related problems like chronic eczema,allergic disorders ,fungal infection like candidiasis ,chronic dermatosis and geriatric dry skin problems, congenital ithyosis.
Dosage
S.I.V.A drops is a 100 % non-toxic for intake in the prescribed dosage. Long term treatment does not produce any cumulative effects in any vital organs.
Adults:
10 drops in hot milk in empty stomach two times a day. Long term treatment is advised in chronic diseases, sexually transmitted diseases,auto immune disorder and immune suppressive disorder.
For children above 10 years:5 drops twice a day with honey/milk in empty stomach.
For children between 5 to 10 years:5 drops once a day with honey/milk in empty stomach.
For children below 5 years: S.I.V.A drops may be given with honey or as directed by the physician
S.I.V.A is also recommended for prescription with G-7, PESIN and CARATOL-E (Also products from Dr. JRK's Siddha Research & Pharmaceuticals Pvt Ltd.) capsules for the indications the respective capsules are meant for.
Contra-indications
There are no known contra-indications or side effects.
Presentation
S.I.V.A drops are presented in 30ml dropper containers.
|
| |
|
| |
|
|
|
